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BeginnerImage Gen12 min read2025-03-01

ComfyUI Complete Setup: RTX 5080 Edition

Install, configure, and benchmark your first ComfyUI workflow with optimal VRAM settings for RTX 5080 and other consumer GPUs.

ComfyUI is the most powerful node-based interface for running local AI image and video generation. This guide gets you from zero to a working workflow on Windows with an NVIDIA GPU.

Hardware Requirements

GPUVRAMRecommended Use
RTX 508016GBFull quality, all models
RTX 409024GBFull quality, batch generation
RTX 3080 16GB16GBFull quality, slower
RTX 3080 10GB10GBReduced resolution
RTX 306012GBStandard models only
Minimum: 6GB VRAM for SD1.5. FLUX requires at least 12GB.

Step 1 — Install Prerequisites

Python 3.10.x (required)

Download from python.org — use exactly 3.10.x, not 3.11 or 3.12.
bash
python --version

Git

bash
git --version

CUDA Toolkit

Download CUDA 12.1 from nvidia.com/cuda-downloads. Match your driver version.
bash
nvcc --version

Step 2 — Clone ComfyUI

bash
cd C:\
git clone https://github.com/comfyanonymous/ComfyUI
cd ComfyUI

Step 3 — Install Dependencies

bash
python -m venv venv


.\venv\Scripts\activate

pip install torch torchvision torchaudio --index-url https://download.pytorch.org/whl/cu121

pip install -r requirements.txt

Step 4 — Install ComfyUI Manager

ComfyUI Manager lets you install custom nodes with one click.

bash
cd custom_nodes
git clone https://github.com/ltdrdata/ComfyUI-Manager
cd ..

Step 5 — Download Your First Model

Place models in ComfyUI/models/checkpoints/

Recommended starter model:
bash

Step 6 — Launch ComfyUI

bash
python main.py


python main.py --gpu-only --highvram

python main.py --lowvram

Open your browser to: http://127.0.0.1:8188

RTX 5080 Optimal Settings

These settings maximize quality and speed on 16GB VRAM:

Batch size: 2–4 images
Resolution: 1024x1024 (SDXL) / 768x512 (video)
Steps: 20–30
CFG Scale: 7.0 (images) / 3.0 (video)
Sampler: dpmpp_2m
Scheduler: karras
VAE: Built-in (bake into checkpoint)
Precision: fp16

Installing Essential Custom Nodes

In ComfyUI Manager, install these nodes first:

  1. 1ComfyUI-Impact-Pack — face detailing, segmentation
  2. 2ComfyUI_IPAdapter_plus — image prompt adapter
  3. 3ComfyUI-AnimateDiff-Evolved — video animation
  4. 4ComfyUI-VideoHelperSuite — video input/output
  5. 5rgthree-comfy — better node organization

Your First Workflow

Once launched, load the default workflow:

  1. 1Click Load in the top menu
  2. 2Select default_workflow.json
  3. 3Change the checkpoint to your downloaded model
  4. 4Click Queue Prompt
You should see your first image generate in 15–30 seconds on an RTX 5080.

Performance Benchmarks

Tested on RTX 5080 16GB:

ModelResolutionStepsTime
SDXL1024x102420~3.2s
FLUX Dev FP81024x102420~8.1s
SD 1.5512x51220~0.8s
LTX Video768x512 97f25~5.4s

Common Issues

"CUDA out of memory" — Add --lowvram to launch command, or reduce batch size to 1. Black images — Wrong VAE. Download the correct VAE for your model. Slow generation — Ensure --gpu-only flag is set and venv is activated. Nodes missing — Open ComfyUI Manager and click "Install Missing Custom Nodes".